Pyoderma Gangrenosum: A Literature Review

Clin Podiatr Med Surg. 2021 Oct;38(4):577-588. doi: 10.1016/j.cpm.2021.06.002.


Pyoderma gangrenosum (PG), which most frequently affects the lower extremity, is a complicated disease state that results from a combination of inflammation, neutrophilic invasion, and genetic predisposition. There may also be certain comorbidities involved or it may be idiopathic. The many variations of PG mean that it often presents and responds differently to various treatments based on the specific case. Overall, there have been improvements in understanding the disease; however, further research should focus on finding better ways to predict and prevent this rapidly progressive, painful disease.

Keywords: Leg ulcer; Neutrophilic dermatoses; Pyoderma gangrenosum.

Publication types

  • Review

MeSH terms

  • Comorbidity
  • Humans
  • Inflammation
  • Pyoderma Gangrenosum* / diagnosis
  • Pyoderma Gangrenosum* / therapy