The Role of Exosomal miRNAs in Glioma: Biological Function and Clinical Application

Front Oncol. 2021 Sep 1;11:686369. doi: 10.3389/fonc.2021.686369. eCollection 2021.

Abstract

Gliomas are complex and heterogeneous central nervous system tumors with poor prognosis. Despite the increasing development of aggressive combination therapies, the prognosis of glioma is generally unsatisfactory. Exosomal microRNA (miRNA) has been successfully used in other diseases as a reliable biomarker and even therapeutic target. Recent studies show that exosomal miRNA plays an important role in glioma occurrence, development, invasion, metastasis, and treatment resistance. However, the association of exosomal miRNA between glioma has not been systemically characterized. This will provide a theoretical basis for us to further explore the relationship between exosomal miRNAs and glioma and also has a positive clinical significance in the innovative diagnosis and treatment of glioma.

Keywords: biomarkers; exosomes; glioma; miRNA; microenvironment.

Publication types

  • Review