Linezolid-induced black hairy tongue in a patient with multidrug-resistant tuberculosis: A case report

Sci Prog. 2021 Jul-Sep;104(3):368504211042982. doi: 10.1177/00368504211042982.


The revised World Health Organization guidelines on multidrug-resistant tuberculosis include linezolid in the core drugs group. Consequently, the use of linezolid for patients with multidrug-resistant tuberculosis is increasing. Common adverse events of long-term linezolid use include bone marrow suppression and neuropathies. However, there is limited information on a rare adverse event, black hairy tongue. Here, we report a case of linezolid-induced black hairy tongue in a patient with multidrug-resistant tuberculosis. The etiology, pathogenesis, diagnosis, and treatment of black hairy tongue are also discussed.

Keywords: Linezolid; tongue; tuberculosis.

Publication types

  • Case Reports

MeSH terms

  • Humans
  • Linezolid / adverse effects
  • Peripheral Nervous System Diseases* / chemically induced
  • Peripheral Nervous System Diseases* / drug therapy
  • Tongue, Hairy* / chemically induced
  • Tongue, Hairy* / drug therapy
  • Tuberculosis, Multidrug-Resistant* / drug therapy


  • Linezolid

Supplementary concepts

  • Black hairy tongue