Self-representation in Kleine-Levin syndrome: a single case fMRI study

Neurocase. 2021 Oct;27(5):396-406. doi: 10.1080/13554794.2021.1974488. Epub 2021 Sep 19.


Kleine-Levin syndrome (KLS) is characterized by recurrent episodes of hypersomnia, compulsive hyperphagia, disinhibition, hypersexuality and self modifications. To investigate the Self, we used afunctional magnetic resonance imaging paradigm evaluating Self-reference processing (SRP) and Self-reference effect (SRE) in a17-year-old male adolescent at the end of an episode. We observed enhanced activations in right hemisphere and posterior areas- associated with physical Self representations- during the SRP condition, while during the SRE condition, enhanced activations in bilateral but prevailing left frontal areas- associated with the conceptual Self. These results suggest amodified Self during aKLS episode being more physically grounded.

Keywords: Kleine-Levine syndrome; frontal; functional magnetic resonance imaging; identity; occipital.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Humans
  • Kleine-Levin Syndrome* / diagnostic imaging
  • Magnetic Resonance Imaging
  • Male