Chenopodin as an anti-inflammatory compound

Nat Prod Res. 2022 Sep;36(17):4435-4438. doi: 10.1080/14786419.2021.1980791. Epub 2021 Sep 21.


Chenopodin is an 11S-type globulin purified from Chenopodium quinoa seeds, which can bind carbohydrates and hemagglutinating human erythrocytes. The present study aimed to evaluate the N-terminal structure of the heterodimeric Chenopodin and its effects in models of inflammation. Chenopodin presented two subunits on its structure and has N-terminal homology with other Chenopodin in 92%. Chenopodin decreased paw edema and neutrophil recruitment induced by carrageenan in mice. Concluding, we demonstrated that Chenopodin exhibits in vivo anti-inflammatory activity.

Keywords: Chenopodin; Chenopodium quinoa; anti-inflammatory activity; in vivo; seeds.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents* / pharmacology
  • Anti-Inflammatory Agents* / therapeutic use
  • Carrageenan / adverse effects
  • Edema* / chemically induced
  • Edema* / drug therapy
  • Humans
  • Inflammation / chemically induced
  • Inflammation / drug therapy
  • Mice


  • Anti-Inflammatory Agents
  • Carrageenan