Kidney Transplant Cortical Necrosis Observed During Pelvic Radiation Therapy

Pract Radiat Oncol. 2022 Jan-Feb;12(1):24-27. doi: 10.1016/j.prro.2021.09.003. Epub 2021 Sep 20.


A 61 year-old female kidney transplant recipient developed radiologic and biopsy-confirmed cortical necrosis in her transplant with elevated serum creatinine levels during concurrent chemoradiation therapy for anal squamous cell carcinoma. Acute anatomic and pathologic changes within a transplanted kidney during chemoradiation therapy have not been described previously in the literature. Further research is required to ascertain the potential significance and long-term clinical consequences of such findings.

Publication types

  • Case Reports

MeSH terms

  • Anus Neoplasms*
  • Carcinoma, Squamous Cell*
  • Female
  • Humans
  • Kidney
  • Kidney Transplantation* / adverse effects
  • Middle Aged
  • Necrosis / etiology