CBFB-MYH11 fusion transcripts distinguish acute myeloid leukemias with distinct molecular landscapes and outcomes

Blood Adv. 2021 Dec 14;5(23):4963-4968. doi: 10.1182/bloodadvances.2021004965.

Abstract

  1. CBFB-MYH11 transcripts and KIT mutations predict relapse in AML.

  2. High-risk CBFB-MYH11 transcripts are associated with distinct transcriptional landscapes and upregulation of early hematopoiesis genes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Core Binding Factor beta Subunit
  • Humans
  • Leukemia, Myeloid, Acute* / diagnosis
  • Leukemia, Myeloid, Acute* / genetics
  • Myosin Heavy Chains
  • Oncogene Proteins, Fusion / genetics

Substances

  • CBFB protein, human
  • Core Binding Factor beta Subunit
  • MYH11 protein, human
  • Oncogene Proteins, Fusion
  • Myosin Heavy Chains