Cognitive Heterogeneity in Alzheimer Clinical Trials: Harnessing Noise to Achieve Meaningfulness

doi:10.1212/WNL.0000000000012027

Editorial

. 2021 Jun 1;96(22):1017-1018.

doi: 10.1212/WNL.0000000000012027.

Cognitive Heterogeneity in Alzheimer Clinical Trials: Harnessing Noise to Achieve Meaningfulness

Rachel F Buckley¹, David S Knopman²

Affiliations

¹ From the Department of Neurology (R.F.B.), Massachusetts General Hospital and Harvard Medical School; Center for Alzheimer Research and Treatment (R.F.B.), Department of Neurology, Brigham and Women's Hospital, Boston, MA; Melbourne School of Psychological Science (R.F.B.), University of Melbourne, VIC, Australia; and Department of Neurology (D.K.), Mayo Clinic, Rochester, MN. rfbuckley@mgh.harvard.edu.
² From the Department of Neurology (R.F.B.), Massachusetts General Hospital and Harvard Medical School; Center for Alzheimer Research and Treatment (R.F.B.), Department of Neurology, Brigham and Women's Hospital, Boston, MA; Melbourne School of Psychological Science (R.F.B.), University of Melbourne, VIC, Australia; and Department of Neurology (D.K.), Mayo Clinic, Rochester, MN.

PMID: 34550902
DOI: 10.1212/WNL.0000000000012027

Editorial

Cognitive Heterogeneity in Alzheimer Clinical Trials: Harnessing Noise to Achieve Meaningfulness

Rachel F Buckley et al. Neurology. 2021.

. 2021 Jun 1;96(22):1017-1018.

doi: 10.1212/WNL.0000000000012027.

Authors

Rachel F Buckley¹, David S Knopman²

Affiliations

¹ From the Department of Neurology (R.F.B.), Massachusetts General Hospital and Harvard Medical School; Center for Alzheimer Research and Treatment (R.F.B.), Department of Neurology, Brigham and Women's Hospital, Boston, MA; Melbourne School of Psychological Science (R.F.B.), University of Melbourne, VIC, Australia; and Department of Neurology (D.K.), Mayo Clinic, Rochester, MN. rfbuckley@mgh.harvard.edu.
² From the Department of Neurology (R.F.B.), Massachusetts General Hospital and Harvard Medical School; Center for Alzheimer Research and Treatment (R.F.B.), Department of Neurology, Brigham and Women's Hospital, Boston, MA; Melbourne School of Psychological Science (R.F.B.), University of Melbourne, VIC, Australia; and Department of Neurology (D.K.), Mayo Clinic, Rochester, MN.

PMID: 34550902
DOI: 10.1212/WNL.0000000000012027

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Finding Treatment Effects in Alzheimer Trials in the Face of Disease Progression Heterogeneity.
Jutten RJ, Sikkes SAM, Van der Flier WM, Scheltens P, Visser PJ, Tijms BM; Alzheimer's Disease Neuroimaging Initiative. Jutten RJ, et al. Neurology. 2021 Jun 1;96(22):e2673-e2684. doi: 10.1212/WNL.0000000000012022. Neurology. 2021. PMID: 34550903 Free PMC article.

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Cognitive Heterogeneity in Alzheimer Clinical Trials: Harnessing Noise to Achieve Meaningfulness

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Cognitive Heterogeneity in Alzheimer Clinical Trials: Harnessing Noise to Achieve Meaningfulness

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