The lesson of ivermectin: meta-analyses based on summary data alone are inherently unreliable

doi:10.1038/s41591-021-01535-y

. 2021 Nov;27(11):1853-1854.

doi: 10.1038/s41591-021-01535-y.

The lesson of ivermectin: meta-analyses based on summary data alone are inherently unreliable

Jack M Lawrence¹, Gideon Meyerowitz-Katz², James A J Heathers³, Nicholas J L Brown⁴, Kyle A Sheldrick⁵

Affiliations

¹ St George's, University of London, London, UK.
² School of Health and Society, University of Wollongong, New South Wales, Australia.
³ Cipher Skin, Denver, CO, USA.
⁴ Linnaeus University, Växjö, Sweden.
⁵ University of New South Wales, Kensington, Australia. k.sheldrick@unsw.edu.au.

PMID: 34552263
DOI: 10.1038/s41591-021-01535-y

The lesson of ivermectin: meta-analyses based on summary data alone are inherently unreliable

Jack M Lawrence et al. Nat Med. 2021 Nov.

. 2021 Nov;27(11):1853-1854.

doi: 10.1038/s41591-021-01535-y.

Authors

Jack M Lawrence¹, Gideon Meyerowitz-Katz², James A J Heathers³, Nicholas J L Brown⁴, Kyle A Sheldrick⁵

Affiliations

¹ St George's, University of London, London, UK.
² School of Health and Society, University of Wollongong, New South Wales, Australia.
³ Cipher Skin, Denver, CO, USA.
⁴ Linnaeus University, Växjö, Sweden.
⁵ University of New South Wales, Kensington, Australia. k.sheldrick@unsw.edu.au.

PMID: 34552263
DOI: 10.1038/s41591-021-01535-y

No abstract available

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Comment in

Meta-analyses based on summary data can provide timely, thorough and reliable evidence: don't dismiss them yet.
Godolphin PJ, Rogozińska E, Fisher DJ, Vale CL, Tierney JF. Godolphin PJ, et al. Nat Med. 2022 Mar;28(3):429-430. doi: 10.1038/s41591-021-01675-1. Nat Med. 2022. PMID: 35145306 No abstract available.

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References

1. Elgazzar, A. et al. Preprint at https://www.researchsquare.com/article/rs-100956/v3 (2020).
1. Bryant, A. et al. Am. J. Ther. 28, e434–e460 (2021). - DOI
1. Hill, A. et al. Open Forum Infectious Diseases https://doi.org/10.1093/ofid/ofab358 (2021).
1. Davey, M. The Guardian https://www.theguardian.com/science/2021/jul/16/huge-study-supporting-iv... (16 July 2021).
1. Elgazzar, A. et al. Preprint at https://doi.org/10.21203/rs.3.rs-100956/v2 (2020).

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[1] Elgazzar, A. et al. Preprint at https://www.researchsquare.com/article/rs-100956/v3 (2020).

[2] Elgazzar, A. et al. Preprint at https://www.researchsquare.com/article/rs-100956/v3 (2020).

[3] Bryant, A. et al. Am. J. Ther. 28, e434–e460 (2021). - DOI

[4] Bryant, A. et al. Am. J. Ther. 28, e434–e460 (2021). - DOI

[5] Hill, A. et al. Open Forum Infectious Diseases https://doi.org/10.1093/ofid/ofab358 (2021).

[6] Hill, A. et al. Open Forum Infectious Diseases https://doi.org/10.1093/ofid/ofab358 (2021).

[7] Davey, M. The Guardian https://www.theguardian.com/science/2021/jul/16/huge-study-supporting-iv... (16 July 2021).

[8] Davey, M. The Guardian https://www.theguardian.com/science/2021/jul/16/huge-study-supporting-iv... (16 July 2021).

[9] Elgazzar, A. et al. Preprint at https://doi.org/10.21203/rs.3.rs-100956/v2 (2020).

[10] Elgazzar, A. et al. Preprint at https://doi.org/10.21203/rs.3.rs-100956/v2 (2020).

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The lesson of ivermectin: meta-analyses based on summary data alone are inherently unreliable

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The lesson of ivermectin: meta-analyses based on summary data alone are inherently unreliable

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