Digital subtraction angiography in cerebrovascular disease: current practice and perspectives on diagnosis, acute treatment and prognosis

Acta Neurol Belg. 2022 Jun;122(3):763-780. doi: 10.1007/s13760-021-01805-z. Epub 2021 Sep 22.


Digital Subtraction Angiography (DSA) is the gold-standard imaging modality in acute cerebrovascular diagnosis. The role of DSA has become increasingly prominent since the incorporation of endovascular therapy in standards of care for acute ischemic stroke. It is used in the assessment of cerebral vessel patency; however, the therapeutic role of DSA from a prognostic standpoint merits further investigation. The current paper provides an update on current practice on diagnostic, therapeutic and prognostic use of DSA in acute cerebrovascular diseases and various indications and perspectives that may apply, or limit its use, in ongoing surveillance or prognosis. Pre-clinical and clinical studies on the aspects, including but not limited to the morphology of cerebrovasculature in acute ischaemic stroke, are required to delineate and inform its prognostic role.

Keywords: Acute ischaemic stroke; Cerebrovascular angiography; Cerebrovascular disease; Digital subtraction angiography (DSA); Interventional neurology; Prognosis; Reperfusion.

MeSH terms

  • Angiography, Digital Subtraction / methods
  • Brain Ischemia*
  • Cerebral Angiography / methods
  • Cerebrovascular Disorders* / diagnostic imaging
  • Cerebrovascular Disorders* / therapy
  • Humans
  • Ischemic Stroke*
  • Prognosis
  • Stroke*