Location Matters: Profiling Diffuse Type Gastric Cancer At the Single-Cell Level

Clin Cancer Res. 2021 Dec 1;27(23):6284-6286. doi: 10.1158/1078-0432.CCR-21-2935. Epub 2021 Sep 23.


Spatial single-cell transcriptomics of primary patient diffuse type gastric cancer reveals distinct cancer and stromal cell differences based on location. Expression of CCL2 by stromal cells in deep tumor regions is highlighted as potentially driving the immunosuppressive microenvironment and enhancing (directly or indirectly) the invasive capacity of tumor cells.See related article by Jeong et al., p. 6529.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Humans
  • Stomach Neoplasms* / diagnosis
  • Stomach Neoplasms* / genetics
  • Stromal Cells
  • Transcriptome
  • Tumor Microenvironment / genetics