Multiple Cardiovascular Diseases or Risk Factors Increase the Severity of Coronavirus Disease 2019

Circ J. 2021 Oct 25;85(11):2111-2115. doi: 10.1253/circj.CJ-21-0684. Epub 2021 Sep 22.


Background: This study aimed to determine whether disease severity varied according to whether coronavirus disease 2019 (COVID-19) patients had multiple or single cardiovascular diseases and risk factors (CVDRFs).Methods and Results:COVID-19 patients with single (n=281) or multiple (n=412) CVDRFs were included retrospectively. Multivariable logistic regression showed no significant difference in the risk of in-hospital death between groups, but patients with multiple CVDRFs had a significantly higher risk of acute respiratory distress syndrome (odds ratio: 1.75, 95% confidence interval: 1.09-2.81).

Conclusions: COVID-19 patients with multiple CVDRFs have a higher risk of complications than those with a single CDVRF.

Keywords: Cardiovascular disease; Cardiovascular risk factors; Coronavirus disease.

Publication types

  • Comparative Study
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • COVID-19 / diagnosis
  • COVID-19 / epidemiology*
  • COVID-19 / mortality
  • COVID-19 / therapy
  • Cardiovascular Diseases / diagnosis
  • Cardiovascular Diseases / epidemiology*
  • Cardiovascular Diseases / mortality
  • Cardiovascular Diseases / therapy
  • Female
  • Health Status
  • Heart Disease Risk Factors
  • Hospital Mortality
  • Humans
  • Japan / epidemiology
  • Male
  • Middle Aged
  • Prognosis
  • Retrospective Studies
  • Risk Assessment
  • Severity of Illness Index