Geographic heterogeneity of chromosome aberrations in hematologic disorders

Cancer Genet Cytogenet. 1986 Feb 15;20(3-4):203-8. doi: 10.1016/0165-4608(86)90075-0.


The incidence of characteristic nonrandom chromosome aberrations in malignant cells of unselected, consecutively studied, and previously untreated patients from various geographic regions has been surveyed. The results demonstrate significant geographic heterogeneity in the distribution of the specific aberrations considered among the four malignant disorders studied in a sufficient number to permit conclusions, viz., acute nonlymphocytic leukemia, chronic myeloid leukemia, polycythemia vera, and myelodysplastic syndrome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Aberrations / epidemiology*
  • Chromosome Disorders
  • Humans
  • Leukemia / genetics*
  • Leukemia, Myeloid / genetics
  • Myelodysplastic Syndromes / genetics*
  • Polycythemia Vera / genetics*
  • Translocation, Genetic