Infection of mice with lactic dehydrogenase virus prevents development of experimental allergic encephalomyelitis

J Neuroimmunol. 1986 Mar;11(1):53-6. doi: 10.1016/0165-5728(86)90074-3.


A significant reduction in the incidence of experimental allergic encephalomyelitis (EAE) in SJL/J mice was observed when mice were infected with lactic dehydrogenase virus (LDV) 14 days before, on day 0, or 3 days after immunization with spinal cord homogenate. These results are discussed in terms of the selective infection by LDV of I-region-associated antigen- (Ia) positive macrophages.

MeSH terms

  • Animals
  • Encephalomyelitis, Autoimmune, Experimental / immunology*
  • Encephalomyelitis, Autoimmune, Experimental / microbiology
  • Encephalomyelitis, Autoimmune, Experimental / prevention & control
  • Histocompatibility Antigens Class II / immunology
  • Immunity, Cellular
  • Immunization
  • Lactate dehydrogenase-elevating virus / immunology*
  • Male
  • Mice
  • Spinal Cord / immunology


  • Histocompatibility Antigens Class II