Preliminary quantitative analysis of vertebral microenvironment changes in type 2 diabetes mellitus using FOCUS IVIM-DWI and IDEAL-IQ sequences

Hui Yang; Xiaojie Cui; Xiuzhu Zheng; Jiang Li; Qianqian Yao; Xiaoqian Li; Jian Qin

doi:10.1016/j.mri.2021.09.008

Preliminary quantitative analysis of vertebral microenvironment changes in type 2 diabetes mellitus using FOCUS IVIM-DWI and IDEAL-IQ sequences

Magn Reson Imaging. 2021 Dec:84:84-91. doi: 10.1016/j.mri.2021.09.008. Epub 2021 Sep 21.

Authors

Hui Yang¹, Xiaojie Cui¹, Xiuzhu Zheng¹, Jiang Li¹, Qianqian Yao¹, Xiaoqian Li¹, Jian Qin²

Affiliations

¹ Department of Radiology, The Second Affiliated Hospital of Shandong First Medical University, Tai'an 271000, Shandong, China.
² Department of Radiology, The Second Affiliated Hospital of Shandong First Medical University, Tai'an 271000, Shandong, China. Electronic address: sdqinjian@126.com.

PMID: 34560231
DOI: 10.1016/j.mri.2021.09.008

Abstract

Purpose: To explore the application of intravoxel incoherent motion diffusion-weighted imaging(IVIM-DWI) on account of field-of-view optimized and constrained undistorted single shot (FOCUS) and iteraterative decomposition of water and fat with echo asymmetry and least-squares estimation quantitation(IDEAL-IQ) sequences in evaluating the vertebral microenvironment changes of type 2 diabetes mellitus(T2DM) patients and the correlation with bone mineral density(BMD).

Method: 128 T2DM patients (mean age 63.4 ± 5.28 years) underwent both dual-energy X-ray absorptiometry (DEXA) and spine MRI. The FOCUS IVIM-DWI and IDEAL-IQ derived parameters of the vertebral body(L1, L2, L3, L4)were measured on corresponding maps of the lumbar spine. The subjects were divided into 3 groups according to T-scores as follows: normal (n = 37), osteopenia (n = 43), and osteoporosis(n = 48) group.One-way analysis of variance (ANOVA) were used to compare the vertebral parameters(ADC_slow, ADC_fast, f, FF, R2*) among three BMD cohorts.Receiver operating characteristic (ROC) analyses and Spearman's rank correlation were performed to test the diagnostic performance and the correlation between them respectively.

Results: There were significant differences in vertebral ADC_slow, ADC_fast, FF and R2* between the three groups (P < 0.05).Statistically, BMD was moderately negatively correlated with FF (r = -0.584, P < 0.001) and weakly positively with ADC_slow (r = 0.334, P < 0.001), meanwhile moderately positively correlated with R2*(r = 0.509, P < 0.001) and ADC_fast(0.545, P < 0.001).ADC_fast was moderately negatively correlated with FF (r = -0.417, P < 0.001), weakly positively correlated with R2*(0.359, P < 0.001).Compared with the area under the curve (AUC) of ADC_slow, ADC_fast, FF and R2*, the AUC of ADC_fast was higher in identifying between normal and abnormal(osteopenia and osteoporosis), normal from osteopenia, while the AUC of FF was higher in identifying osteopenia from osteoporosis.

Conclusions: FOCUS IVIM-DWI and IDEAL-IQ of lumbar spine might be useful to evaluate the vertebral microenvironment changes of T2DM patients.

Keywords: Intravoxel incoherent motion;diffusion magnetic resonance imaging;fat fraction; Lumbar spine; Osteoporosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Diabetes Mellitus, Type 2* / diagnostic imaging
Diffusion Magnetic Resonance Imaging
Humans
Lumbar Vertebrae / diagnostic imaging
Magnetic Resonance Imaging
Middle Aged
Osteoporosis* / diagnostic imaging