Cluster dirhenium(III) cis-dicarboxylates with α-amino acids ligands as mighty selective G4s binders

J Inorg Biochem. 2021 Dec:225:111605. doi: 10.1016/j.jinorgbio.2021.111605. Epub 2021 Sep 15.

Abstract

The synthesis of four dirhenium(III) cis-dicarboxylates with the α-amino acids residues Asp (I), Glu (II), Phe (III) and Tyr (IV) is presented. The G-quadruplex stabilization potential was evaluated by fluorescence resonance energy transfer - melting analysis. All derivatives show specific binding to c-kit1 quadruplex, while II and IV have also strong stabilization activity to HTelo21 quadruplex. At the same time, the compounds do not show any stabilization activity for ds26 DNA, which suggests unique mechanisms of molecular DNA recognition for these complexes.

Keywords: Amino acid; Cluster compound; Fluorescence resonance energy transfer (FRET); G–quadruplex; Rhenium.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemical synthesis
  • Amino Acids / metabolism*
  • Coordination Complexes / chemical synthesis
  • Coordination Complexes / metabolism*
  • DNA / genetics
  • DNA / metabolism*
  • Fluorescence Resonance Energy Transfer
  • G-Quadruplexes*
  • Humans
  • Ligands
  • Molecular Structure
  • Rhenium / chemistry

Substances

  • Amino Acids
  • Coordination Complexes
  • Ligands
  • Rhenium
  • DNA