A multifunctional, one-step gas foaming strategy for antimicrobial silver nanoparticle-decorated 3D cellulose nanofiber scaffolds

Joon Yeon Moon; Joshua Lee; Tae In Hwang; Chan Hee Park; Cheol Sang Kim

doi:10.1016/j.carbpol.2021.118603

A multifunctional, one-step gas foaming strategy for antimicrobial silver nanoparticle-decorated 3D cellulose nanofiber scaffolds

Carbohydr Polym. 2021 Dec 1:273:118603. doi: 10.1016/j.carbpol.2021.118603. Epub 2021 Aug 25.

Authors

Joon Yeon Moon¹, Joshua Lee², Tae In Hwang³, Chan Hee Park⁴, Cheol Sang Kim⁵

Affiliations

¹ Department of Bionanotechnology and Bioconvergence Engineering, Graduate School, Jeonbuk National University, Jeonju 54896, Republic of Korea.
² Department of Bionanotechnology and Bioconvergence Engineering, Graduate School, Jeonbuk National University, Jeonju 54896, Republic of Korea. Electronic address: jjangwon21@gmail.com.
³ Department of Family Medicine, Wonkwang University Hospital, Iksan 54538, Republic of Korea.
⁴ Department of Bionanotechnology and Bioconvergence Engineering, Graduate School, Jeonbuk National University, Jeonju 54896, Republic of Korea; Division of Mechanical Design Engineering, Jeonbuk National University, Jeonju 54896, Republic of Korea. Electronic address: biochan@jbnu.ac.kr.
⁵ Department of Bionanotechnology and Bioconvergence Engineering, Graduate School, Jeonbuk National University, Jeonju 54896, Republic of Korea; Division of Mechanical Design Engineering, Jeonbuk National University, Jeonju 54896, Republic of Korea. Electronic address: chskim@jbnu.ac.kr.

PMID: 34561003
DOI: 10.1016/j.carbpol.2021.118603

Abstract

Creating nanoparticle-decorated nanofibers in a single step can greatly speed up and scale up the production of scaffolds for various applications. In this study, we report a facile multifunctional method for the simultaneous foaming and synthesis of silver nanoparticles-covered three-dimensional cellulose using sodium borohydride (NaBH4). The physicochemical properties of the 3D cellulose-Ag scaffold were evaluated and compared to 2D CA membranes, including morphology (porous 3D vs flat 2D), mechanical properties (22.72 vs <13 MPa Young's modulus), antibacterial effect (27 vs 0 mm zone of inhibition), and biocompatibility. The findings suggest that our method enables the scaffold to be easily manufactured-indicating it can be used to scale-up manufacturing processes-with high bioactivity, antibacterial effect, and biocompatibility, showing potential as a 3D structure production method for tissue engineering and other relevant applications.

Keywords: 3D nanofibers; Multifunctional gas foaming; Regenerated cellulose; Silver nanoparticles; Wound dressing.