Epidermal Growth Factor in Aesthetics and Regenerative Medicine: Systematic Review

J Cutan Aesthet Surg. 2021 Apr-Jun;14(2):137-146. doi: 10.4103/JCAS.JCAS_25_20.


Introduction: Epidermal Growth Factor (rhEGF) is a promising skin antiaging agent that successfully promotes skin wound repair, and it has been investigated in the past decade for these purposes. However, there are no updated systematic reviews, in English or English, that support the efficacy of rhEGF as a regenerative skin treatment or systematic reviews that compile the uses of rhEGF as facial aesthetic therapy and regenerative medicine.

Aim: To describe the current state of facial aesthetic and regenerative medicine treatments in which rhEGF has been effectively used.

Materials and methods: An exhaustive search was carried out in "Medline" (via "PubMed"), "Cochrane," "Bireme" through the Virtual Health Library (VHL), "Elsevier" via "Science Direct," "Springer," "SciELo," "ResearchGate," and Google Scholar. Studies related to the use of rhEGF in addressing skin disorders or skin aging are included.

Results: Overall, 49 articles were found, which described the use of rhEGF for skin regeneration and restructuring. Efficacy in the regeneration of skin wounds was verified through the intradermal and topical application of formulations with rhEGF. Most clinical trials in aesthetics point to an effective inversion of skin aging. However, uncontrolled or randomized trials abound, so that does not represent enough evidence to establish its efficiency. There are transient adverse effects for both cases.

Conclusion: The rhEGF considers an effective therapeutic alternative for patients with recalcitrant skin wounds and skin aging, as it is a potent and specific mitogenic factor for the skin.

Keywords: Epidermal growth factor; facial aesthetics; regenerative medicine; skin aging; skin ulcers; ✓ In both cases, it is necessary to biostimulate fibroblasts and keratinocytes, inducing dermal restructuring.; ✓ Similarities exist between the aging skin and wound healing, and mostly they involve the same oxidation and repair mechanisms; ✓ The EFG is more effectively applied by intradermal injections and using transdermal patches, thereby reducing the rhytids, folds, and hyperpigmentation and accelerating wound healing..

Publication types

  • Review