The effects of extended-wear hydrophilic contact lenses on the human corneal epithelium

Am J Ophthalmol. 1986 Mar 15;101(3):274-7. doi: 10.1016/0002-9394(86)90818-4.


We used wide-field color specular microscopy of the human corneal surface to study the morphologic changes that occur under extended-wear contact lenses. There was a shift in the frequency distribution of surface cells by size to larger cells, suggesting a prolonged residence time on the ocular surface. Other abnormalities included retained desiccated mucin, coarse mucus plaques, and palisading of cells.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aphakia, Postcataract / therapy
  • Contact Lenses, Extended-Wear / adverse effects*
  • Contact Lenses, Hydrophilic / adverse effects*
  • Cornea / pathology*
  • Cornea / ultrastructure
  • Epithelium / pathology
  • Epithelium / ultrastructure
  • Humans
  • Microscopy, Electron, Scanning
  • Middle Aged
  • Myopia / therapy