Febrile neutropenia following with single-low-dose methotrexate for the treatment of ectopic pregnancy: a case report

Pan Afr Med J. 2021 Jan 7;38:17. doi: 10.11604/pamj.2021.38.17.27507. eCollection 2021.


Methotrexate (MTX) is an effective, economical and safe drug used in the treatment of ectopic pregnancy. Complications are very rare. Herein, we reported a case of febrile neutropenia following single low-dose methotrexate for the treatment of ectopic pregnancy. Febrile neutropenia developed on day 4 of single-dose methotrexate administered intramuscularly. Although methotrexate single-dose regimen is quite effective and safe in ectopic pregnancy, febrile neutropenia can occur very rarely.

Keywords: Ectopic pregnancy; case report; medical therapy; methotrexate; pharmacogenetics.

Publication types

  • Case Reports

MeSH terms

  • Abortifacient Agents, Nonsteroidal / administration & dosage
  • Abortifacient Agents, Nonsteroidal / adverse effects*
  • Adult
  • Febrile Neutropenia / chemically induced*
  • Female
  • Humans
  • Injections, Intramuscular
  • Methotrexate / administration & dosage
  • Methotrexate / adverse effects*
  • Pregnancy
  • Pregnancy, Ectopic / drug therapy


  • Abortifacient Agents, Nonsteroidal
  • Methotrexate