Integrated sensing and delivery of oxygen for next-generation smart wound dressings

Manuel Ochoa; Rahim Rahimi; Jiawei Zhou; Hongjie Jiang; Chang Keun Yoon; Dinesh Maddipatla; Binu Baby Narakathu; Vaibhav Jain; Mark Michael Oscai; Thaddeus Joseph Morken; Rebeca Hannah Oliveira; Gonzalo L Campana; Oscar W Cummings; Michael A Zieger; Rajiv Sood; Massood Z Atashbar; Babak Ziaie

doi:10.1038/s41378-020-0141-7

Integrated sensing and delivery of oxygen for next-generation smart wound dressings

Microsyst Nanoeng. 2020 May 18:6:46. doi: 10.1038/s41378-020-0141-7. eCollection 2020.

Authors

Manuel Ochoa^{1

2}, Rahim Rahimi^{1

2

3}, Jiawei Zhou^{1

2}, Hongjie Jiang^{1

2

4}, Chang Keun Yoon^{1

2}, Dinesh Maddipatla⁵, Binu Baby Narakathu⁵, Vaibhav Jain^{2

6}, Mark Michael Oscai^{1

2}, Thaddeus Joseph Morken^{1

2}, Rebeca Hannah Oliveira^{1

2}, Gonzalo L Campana⁷, Oscar W Cummings⁸, Michael A Zieger⁷, Rajiv Sood⁷, Massood Z Atashbar⁵, Babak Ziaie^{1

2

9}

Affiliations

¹ School of Electrical and Computer Engineering, Purdue University, West Lafayette, 47907 IN USA.
² Birck Nanotechnololgy Center, 1205W State Street, West Lafayette, 47907 IN USA.
³ School of Material Science Engineering, Purdue University, West Lafayette, 47907 IN USA.
⁴ Present Address: Shenzhen MSU-BIT University, Shenzhen, China.
⁵ Electrical and Computer Engineering Department, Western Michigan University, 4601 Campus Drive B-236, Kalamazoo, 49008 MI USA.
⁶ School of Mechanical Engineering, Purdue University, West Lafayette, 47907 IN USA.
⁷ Indiana University School of Medicine, 980 West Walnut Street, Building R3 Room C634, Indianapolis, 46202 IN USA.
⁸ Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, IU Health Pathology Laboratory, 350W 11th Street, Room 4054, Indianapolis, IN 46202 USA.
⁹ Weldon School of Biomedical Engineering, Purdue University, West Lafayette, 47907 IN USA.

Abstract

Chronic wounds affect over 6.5 million Americans and are notoriously difficult to treat. Suboptimal oxygenation of the wound bed is one of the most critical and treatable wound management factors, but existing oxygenation systems do not enable concurrent measurement and delivery of oxygen in a convenient wearable platform. Thus, we developed a low-cost alternative for continuous O₂ delivery and sensing comprising of an inexpensive, paper-based, biocompatible, flexible platform for locally generating and measuring oxygen in a wound region. The platform takes advantage of recent developments in the fabrication of flexible microsystems including the incorporation of paper as a substrate and the use of a scalable manufacturing technology, inkjet printing. Here, we demonstrate the functionality of the oxygenation patch, capable of increasing oxygen concentration in a gel substrate by 13% (5 ppm) in 1 h. The platform is able to sense oxygen in a range of 5-26 ppm. In vivo studies demonstrate the biocompatibility of the patch and its ability to double or triple the oxygen level in the wound bed to clinically relevant levels.

Keywords: Biosensors; Electrical and electronic engineering; Microfluidics.