The Use of Standardized Diesel Exhaust Particles in Alzheimer's Disease Research

J Alzheimers Dis. 2021;84(2):607-608. doi: 10.3233/JAD-215201.


The mechanisms underlying how urban air pollution exposure conveys Alzheimer's disease risk and affects plaque pathology is largely unknown. Because particulate matter, the particle component of urban air pollution, varies across location, pollution source, and time, a single model representative of all ambient particulate matter is unfeasible for research investigating the role of ar pollution in central nervous system diseases. More specifically, the investigation of several models of particulate matter with enrichment of source-specific components are essential to employ, in order to more fully understand what characteristics of particulate matter affects Alzheimer's disease, including standardized diesel exhaust particles.

Keywords: Air pollution; Alzheimer’s disease; diesel exhaust particles; particulate matter models.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Air Pollution / adverse effects*
  • Alzheimer Disease / complications*
  • Biomedical Research*
  • Humans
  • Particulate Matter / adverse effects*
  • Particulate Matter / standards
  • Vehicle Emissions / toxicity*


  • Particulate Matter
  • Vehicle Emissions