Diet and chronic atrophic gastritis: a case-control study

J Natl Cancer Inst. 1986 Apr;76(4):621-7. doi: 10.1093/jnci/76.4.621.

Abstract

A hospital-based case-control study of gastric cancer precursor lesions was conducted in a high-risk black population in southern Louisiana. Ninety-three subjects with biopsy-proved advanced chronic atrophic gastritis were compared to two control series: a gastroscopy clinic series and a general hospital-admission series. Dietary case-control differences indicated a protective effect associated with fruit and vegetable intake and with dietary vitamin C and a risk elevation associated with milk consumption. The protective effect associated with consumption of fruits, vegetables, and vitamin C is consistent with findings for gastric cancer and with the etiologic hypothesis of intragastric nitrosation. A twofold increased risk was associated with cigarette smoking. Gastric juice pH, NO3-, and NO2- were determined for subjects undergoing gastroscopy, and comparisons were made between this high-risk U.S. group and a Colombian population with a much greater magnitude of risk; the latter had higher NO3- and NO2- levels. An increase in pH was associated with increasing severity of gastric lesions. Levels of pH and NO2- concentration were significantly correlated (P less than .0005); however, in Louisiana the large difference in NO2- concentration associated with pH elevation is not associated with histopathologic severity. Divergent trends with severity of lesions for NO3- concentration were seen in the two populations.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • African Continental Ancestry Group
  • Age Factors
  • Aged
  • Animals
  • Ascorbic Acid / administration & dosage
  • Chronic Disease
  • Diet*
  • Female
  • Fruit
  • Gastric Acidity Determination
  • Gastric Juice / analysis
  • Gastritis / etiology*
  • Gastritis, Atrophic / etiology*
  • Humans
  • Male
  • Middle Aged
  • Milk
  • Nitrates / analysis
  • Nitrites / analysis
  • Sex Factors
  • Smoking
  • Sodium Chloride / administration & dosage
  • Stomach Neoplasms / etiology
  • Vegetables

Substances

  • Nitrates
  • Nitrites
  • Sodium Chloride
  • Ascorbic Acid