The Effects of Korean Red Ginseng on Biological Aging and Antioxidant Capacity in Postmenopausal Women: A Double-Blind Randomized Controlled Study

Nutrients. 2021 Sep 2;13(9):3090. doi: 10.3390/nu13093090.


Postmenopausal women are vulnerable to aging and oxidative stress due to reduced estrogen. Previous studies have shown that Korean red ginseng (KRG) has beneficial effects on aging and antioxidant capacity. Therefore, we evaluated the effects of KRG on biological aging and antioxidant capacity in postmenopausal women. This study conducted a double-blinded, placebo-controlled clinical trial. The participants were randomly administered KRG or a placebo, and the following metrics were measured: mitochondria DNA (mtDNA) copy number as an indicator of biological aging and, total antioxidant status (TAS) as a marker of antioxidant capacity. Clinical symptoms of fatigue, as measured by the fatigue severity scale, were assessed before and after KRG administration. There were 63 participants, of whom 33 received KRG and 30 received a placebo. The mtDNA copy number (KRG group: 1.58 ± 2.05, placebo group: 0.28 ± 2.36, p = 0.023) and TAS (KRG group: 0.11 ± 0.25 mmol/L, placebo group: -0.04 ± 0.16 mmol/L, p = 0.011) increased and the fatigue severity scale (KRG group: -7 ± 12, placebo group: -1 ± 11, p = 0.033) decreased significantly more in the KRG group than the placebo group. KRG significantly increased the mtDNA copy number, total antioxidant status, and improved symptoms of fatigue in postmenopausal women.

Keywords: Korean red ginseng; antioxidant activity; biological aging; fatigue; postmenopausal women.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Aging / drug effects*
  • Antioxidants / administration & dosage*
  • Antioxidants / analysis
  • DNA, Mitochondrial / blood
  • Double-Blind Method
  • Female
  • Ginsenosides / administration & dosage
  • Humans
  • Middle Aged
  • Panax / chemistry*
  • Placebos
  • Plant Extracts / administration & dosage*
  • Postmenopause*
  • Republic of Korea


  • Antioxidants
  • DNA, Mitochondrial
  • Ginsenosides
  • Placebos
  • Plant Extracts