Intermittent Fasting and the Possible Benefits in Obesity, Diabetes, and Multiple Sclerosis: A Systematic Review of Randomized Clinical Trials

Nutrients. 2021 Sep 13;13(9):3179. doi: 10.3390/nu13093179.


Intermittent fasting has become popular in recent years and is controversially presented as a possible therapeutic adjunct. A bibliographic review of the literature on intermittent fasting and obesity, diabetes, and multiple sclerosis was carried out. The scientific quality of the methodology and the results obtained were evaluated in pairs. Intermittent fasting has beneficial effects on the lipid profile, and it is associated with weight loss and a modification of the distribution of abdominal fat in people with obesity and type 2 diabetes as well as an improvement in the control of glycemic levels. In patients with multiple sclerosis, the data available are too scarce to draw any firm conclusions, but it does appear that intermittent fasting may be a safe and feasible intervention. However, it is necessary to continue investigating its long-term effects since so far, the studies carried out are small and of short duration.

Keywords: exercise; intermittent fasting; multiple sclerosis; obesity; type 2 diabetes.

Publication types

  • Systematic Review

MeSH terms

  • Diabetes Mellitus, Type 2 / diet therapy*
  • Fasting*
  • Glycemic Control
  • Humans
  • Multiple Sclerosis / diet therapy*
  • Obesity / diet therapy*
  • Randomized Controlled Trials as Topic