Maternal Fructose Diet-Induced Developmental Programming

Nutrients. 2021 Sep 20;13(9):3278. doi: 10.3390/nu13093278.


Developmental programming of chronic diseases by perinatal exposures/events is the basic tenet of the developmental origins hypothesis of adult disease (DOHaD). With consumption of fructose becoming more common in the diet, the effect of fructose exposure during pregnancy and lactation is of increasing relevance. Human studies have identified a clear effect of fructose consumption on maternal health, but little is known of the direct or indirect effects on offspring. Animal models have been utilized to evaluate this concept and an association between maternal fructose and offspring chronic disease, including hypertension and metabolic syndrome. This review will address the mechanisms of developmental programming by maternal fructose and potential options for intervention.

Keywords: developmental origins hypothesis of adult disease (DOHaD); diabetes; fructose; hypertension; metabolic syndrome; metabolism; obesity; uric acid.

Publication types

  • Review

MeSH terms

  • Animals
  • Female
  • Fructose / adverse effects*
  • Humans
  • Hypertension / chemically induced
  • Maternal Nutritional Physiological Phenomena / drug effects
  • Metabolic Syndrome / chemically induced
  • Pregnancy
  • Prenatal Exposure Delayed Effects / chemically induced*


  • Fructose