Altered mental status and pronounced febrile response after second mRNA-1273 (Moderna) COVID-19 vaccine administration in a patient with previously documented COVID-19 infection

Patrick Shamell Hilaire; Emmanuel Tito; Nirmal Muthukumarasamy; Mark Schauer

doi:10.1136/bcr-2021-244119

Altered mental status and pronounced febrile response after second mRNA-1273 (Moderna) COVID-19 vaccine administration in a patient with previously documented COVID-19 infection

BMJ Case Rep. 2021 Sep 27;14(9):e244119. doi: 10.1136/bcr-2021-244119.

Authors

Patrick Shamell Hilaire¹, Emmanuel Tito², Nirmal Muthukumarasamy², Mark Schauer²

Affiliations

¹ Internal Medicine, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, Michigan, USA patrick.hilaire@med.wmich.edu.
² Internal Medicine, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, Michigan, USA.

Abstract

A 54-year-old man who was previously found to be COVID-19 positive received two doses of mRNA-1273 (Moderna) vaccine 4 weeks apart, as recommended by the manufacturer. He was brought to the emergency department 1 day after second dose of the vaccine with altered mental status, headache and high fever. The patient was hospitalised for 2 days and managed with supportive care. He completely recovered with return of mental status to baseline and resolution of fever.

Keywords: COVID-19; infectious diseases.

Publication types

Case Reports

MeSH terms

COVID-19 Vaccines*
COVID-19*
Fever / etiology
Humans
Male
Middle Aged
RNA, Messenger
SARS-CoV-2

Substances

COVID-19 Vaccines
RNA, Messenger