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. 2021 Nov 18;42(6):721-725.
doi: 10.24272/j.issn.2095-8137.2021.136.

Sox9 is indispensable for testis differentiation in the red-eared slider turtle, a reptile with temperature-dependent sex determination

Hang-Bo Hui  1 , Ling Xiao  1 , Wei Sun  1 , Ying-Jie Zhou  1 , Hai-Yan Zhang  1 , Chu-Tian Ge  2
Affiliations
Free PMC article

Sox9 is indispensable for testis differentiation in the red-eared slider turtle, a reptile with temperature-dependent sex determination

Hang-Bo Hui et al. Zool Res. .
Free PMC article
No abstract available

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Figures

Figure 1
Figure 1
Complete sex reversal induced by Sox9 knockdown
Figure 2
Figure 2
Partial female-to-male sex reversal induced by Sox9 overexpression
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References

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    1. Chaboissier MC, Kobayashi A, Vidal VI P, Lützkendorf S, van de Kant HJG, Wegner M, et al Functional analysis of Sox8 and Sox9 during sex determination in the mouse . Development. 2004;131(9):1891–1901. doi: 10.1242/dev.01087. - DOI - PubMed
    1. Croft B, Ohnesorg T, Hewitt J, Bowles J, Quinn A, Tan J, et al Human sex reversal is caused by duplication or deletion of core enhancers upstream of SOX9 . Nature Communications. 2018;9(1):5319. doi: 10.1038/s41467-018-07784-9. - DOI - PMC - PubMed

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Grants and funding

This study was supported by the National Key Research and Development Program (2018YFD0900203), National Natural Science Foundation of China (31922084, 31872960), Natural Science Foundation of Zhejiang Province for Distinguished Young Scholars (LR19C190001), and Key Agricultural Project of Ningbo (2019C10018)