HPV-related head and neck cancers: Pathology and biology

J Surg Oncol. 2021 Nov;124(6):923-930. doi: 10.1002/jso.26683. Epub 2021 Sep 28.


Discovering the key role HPV plays in head and neck carcinogenesis has revolutionized our approach to cancers such as oropharyngeal carcinomas. As the role of HPV expands beyond the oropharynx, there is a pursued need to understand the oncogenic mechanisms of HPV-driven tumorigenesis and their implications. Optimizing HPV detection methods all while acknowledging their limitations will ensure our ability to diagnose HPV-driven neoplasia wherever clinically relevant.

Keywords: detection methods; human papillomavirus; oropharyngeal carcinoma.

Publication types

  • Review

MeSH terms

  • Head and Neck Neoplasms / pathology*
  • Head and Neck Neoplasms / virology*
  • Humans
  • Papillomaviridae / isolation & purification*
  • Papillomavirus Infections / pathology*
  • Papillomavirus Infections / virology*