Orchestrating human neocortex development across the scales; from micro to macro

Semin Cell Dev Biol. 2022 Oct:130:24-36. doi: 10.1016/j.semcdb.2021.09.007. Epub 2021 Sep 25.


How our brains have developed to perform the many complex functions that make us human has long remained a question of great interest. Over the last few decades, many scientists from a wide range of fields have tried to answer this question by aiming to uncover the mechanisms that regulate the development of the human neocortex. They have approached this on different scales, focusing microscopically on individual cells all the way up to macroscopically imaging entire brains within living patients. In this review we will summarise these key findings and how they fit together.

Keywords: Development; Human neocortex; Shape; Size.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Neocortex*