Commandeering the mammalian Ago2 miRNA network: a newly discovered mechanism of helminth immunomodulation

Trends Parasitol. 2021 Dec;37(12):1031-1033. doi: 10.1016/j.pt.2021.09.001. Epub 2021 Sep 25.

Abstract

MicroRNAs (miRNAs) are a class of noncoding RNAs that contribute to a broad range of biological processes through post-transcriptional regulation of gene expression. Helminths exploit this system to target mammalian gene expression, to modulate the host immune response. Recent discoveries have shed new light on the mechanisms involved.

Keywords: Argonaut; Fasciola hepatica; extracellular vesicles; helminth; microRNAs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Fasciola hepatica* / genetics
  • Helminths* / genetics
  • Immunity
  • Immunomodulation
  • Mammals
  • MicroRNAs* / genetics

Substances

  • MicroRNAs