Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2

Yuanchao Xie; Wanchao Yin; Yumin Zhang; Weijuan Shang; Zhen Wang; Xiaodong Luan; Guanghui Tian; Haji A Aisa; Yechun Xu; Gengfu Xiao; Jia Li; Hualiang Jiang; Shuyang Zhang; Leike Zhang; H Eric Xu; Jingshan Shen

doi:10.1038/s41422-021-00570-1

Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2

Cell Res. 2021 Nov;31(11):1212-1214. doi: 10.1038/s41422-021-00570-1. Epub 2021 Sep 28.

Authors

Yuanchao Xie^#¹, Wanchao Yin^#¹, Yumin Zhang^#², Weijuan Shang², Zhen Wang¹, Xiaodong Luan^{3

4

5}, Guanghui Tian⁶, Haji A Aisa^{7

8}, Yechun Xu^{1

7}, Gengfu Xiao^{2

7}, Jia Li^{1

7

9}, Hualiang Jiang^{1

7

9}, Shuyang Zhang^{3

4

5}, Leike Zhang^{10

11}, H Eric Xu^{12

13}, Jingshan Shen^{14

15}

Affiliations

¹ Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
² State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China.
³ School of Medicine, Tsinghua University, Beijing, China.
⁴ Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
⁵ Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.
⁶ Vigonvita Life Science Co., Ltd., Suzhou, Jiangsu, China.
⁷ University of Chinese Academy of Sciences, Beijing, China.
⁸ Key Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, Xinjiang, China.
⁹ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
¹⁰ State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China. zhangleike@wh.iov.cn.
¹¹ University of Chinese Academy of Sciences, Beijing, China. zhangleike@wh.iov.cn.
¹² Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. eric.xu@simm.ac.cn.
¹³ University of Chinese Academy of Sciences, Beijing, China. eric.xu@simm.ac.cn.
¹⁴ Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. shenjingshan@simm.ac.cn.
¹⁵ University of Chinese Academy of Sciences, Beijing, China. shenjingshan@simm.ac.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adenosine Monophosphate / administration & dosage
Adenosine Monophosphate / analogs & derivatives*
Adenosine Monophosphate / chemistry
Administration, Oral
Alanine / administration & dosage
Alanine / analogs & derivatives*
Alanine / chemistry
Animals
Antiviral Agents / administration & dosage*
Antiviral Agents / chemistry
COVID-19 Drug Treatment
Clinical Studies as Topic
Humans
Mice
Rats

Substances

Antiviral Agents
remdesivir
Adenosine Monophosphate
Alanine

Publication types

MeSH terms

Substances

Grants and funding