Increased frequency of DR2 in patients with aplastic anaemia and increased DR sharing in their parents

B Chapuis; V E Von Fliedner; M Jeannet; H Merica; P Vuagnat; A Gratwohl; C Nissen; B Speck

doi:10.1111/j.1365-2141.1986.tb07494.x

Increased frequency of DR2 in patients with aplastic anaemia and increased DR sharing in their parents

Br J Haematol. 1986 May;63(1):51-7. doi: 10.1111/j.1365-2141.1986.tb07494.x.

Authors

B Chapuis, V E Von Fliedner, M Jeannet, H Merica, P Vuagnat, A Gratwohl, C Nissen, B Speck

PMID: 3458502
DOI: 10.1111/j.1365-2141.1986.tb07494.x

Abstract

68 patients with aplastic anaemia, their parents and healthy siblings were typed for HLA-A, B and DR antigens. Among the patients there is an overrepresentation of DR2. The parents of affected children show an increased compatibility at the DR locus. This situation could favour the expression of recessive gene(s) involved in haematopoiesis and located in the HLA locus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Anemia, Aplastic / genetics
Anemia, Aplastic / immunology*
HLA Antigens / analysis*
HLA-A Antigens
HLA-B Antigens
HLA-DR Antigens
Histocompatibility Antigens Class II / analysis*
Histocompatibility Antigens Class II / genetics
Humans
Parents

Substances

HLA Antigens
HLA-A Antigens
HLA-B Antigens
HLA-DR Antigens
Histocompatibility Antigens Class II