Low-molecular-weight heparin-associated multiple digital necrosis in a patient as a result of heparin-induced thrombocytopenia syndrome

North Clin Istanb. 2020 Aug 31;8(4):402-404. doi: 10.14744/nci.2020.37531. eCollection 2021.


Heparin-induced thrombocytopenia syndrome (HITS) is a rare complication of low-molecular-weight heparin (LMWH). It is an autoimmune-mediated side effect of LMWH which is caused by platelet-activating antibodies that recognize platelet factor-4/ heparin complexes. Although HITS often leads to thrombosis in large veins and arteries, it can be presented as microvascular thrombosis. In this article, we report a case of HITS complicated with multiple digital necrosis after administration of LMWH.

Keywords: Heparin; heparin-induced thrombocytopenia; low-molecular weight heparin; thrombocytopenia.

Publication types

  • Case Reports