Endovascular treatment for acute ischemic stroke in patients with versus without atrial fibrillation: a matched-control study

BMC Neurol. 2021 Sep 29;21(1):377. doi: 10.1186/s12883-021-02386-3.


Background and objective: The effect of atrial fibrillation (AF) on outcomes of endovascular treatment (EVT) for acute ischemic stroke (AIS) is controversial. This study aimed to investigate the association of AF with outcomes after EVT in AIS patients.

Methods: Subjects were selected from ANGEL-ACT registry (Endovascular Treatment Key Technique and Emergency Work Flow Improvement of Acute Ischemic Stroke) - a prospective consecutive cohort of AIS patients undergoing EVT at 111 hospitals in China between November 2017 and March 2019, and then grouped according to having a history of AF or not. After 1:1 propensity score matching, the outcome measures including the 90-day modified Rankin Scale (mRS) score, successful recanalization after final attempt, symptomatic intracranial hemorrhage (ICH) within 24 h, and death within 90 days were compared.

Results: A total of 1755 patients, 550 with AF and 1205 without AF, were included. Among 407 pairs of patients identified after matching, no significant differences were found in the mRS score (median: 3 vs. 3 points; P = 0.29), successful recanalization (87.2 vs. 85.3%; P = 0.42), symptomatic ICH (9. 4 vs. 9.1%; P = 0.86) and death (16.3 vs. 18.4%; P = 0.44) between patients with and without AF.

Conclusion: The findings of this matched-control study show comparable outcomes of EVT in Chinese AIS patients with and without AF, which do not support withholding EVT in patients with both AIS and AF.

Trial registration: NCT03370939 First registration date: 28/09/2017 First posted date: 13/12/2017.

Keywords: Atrial fibrillation; Endovascular treatment; Ischemic stroke; Propensity score matching.

MeSH terms

  • Atrial Fibrillation* / complications
  • Atrial Fibrillation* / epidemiology
  • Atrial Fibrillation* / therapy
  • Brain Ischemia* / complications
  • Brain Ischemia* / epidemiology
  • Brain Ischemia* / therapy
  • Endovascular Procedures*
  • Humans
  • Ischemic Stroke*
  • Prospective Studies
  • Stroke* / complications
  • Stroke* / epidemiology
  • Stroke* / therapy
  • Treatment Outcome

Associated data

  • ClinicalTrials.gov/NCT03370939