Systems biology analysis of lung fibrosis-related genes in the bleomycin mouse model

Sci Rep. 2021 Sep 29;11(1):19269. doi: 10.1038/s41598-021-98674-6.

Abstract

Tissue fibrosis is a major driver of pathology in aging and is involved in numerous age-related diseases. The lungs are particularly susceptible to fibrotic pathology which is currently difficult to treat. The mouse bleomycin-induced fibrosis model was developed to investigate lung fibrosis and widely used over the years. However, a systematic analysis of the accumulated results has not been performed. We undertook a comprehensive data mining and subsequent manual curation, resulting in a collection of 213 genes (available at the TiRe database, www.tiredb.org ), which when manipulated had a clear impact on bleomycin-induced lung fibrosis. Our meta-analysis highlights the age component in pulmonary fibrosis and strong links of related genes with longevity. The results support the validity of the bleomycin model to human pathology and suggest the importance of a multi-target therapeutic strategy for pulmonary fibrosis treatment.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bleomycin / administration & dosage
  • Bleomycin / toxicity
  • Data Mining
  • Datasets as Topic
  • Disease Models, Animal
  • Gene Expression Regulation / drug effects
  • Humans
  • Longevity / genetics*
  • Lung / drug effects
  • Lung / pathology*
  • Mice
  • Pulmonary Fibrosis / chemically induced
  • Pulmonary Fibrosis / genetics*
  • Pulmonary Fibrosis / pathology
  • Systems Biology

Substances

  • Bleomycin