Citrate-based mussel-inspired magnesium whitlockite composite adhesives augmented bone-to-tendon healing

J Mater Chem B. 2021 Oct 13;9(39):8202-8210. doi: 10.1039/d1tb01710a.

Abstract

Citrate-based mussel-inspired whitlockite composite adhesives (CMWAs) were developed and administered to the bone-tendon interface in anterior cruciate ligament (ACL) reconstruction. CMWAs could improve the initial bone-tendon bonding strength, promote the bony inward growth from the bone tunnel and enhance the chondrogenesis and osteogenesis of the bone-tendon interface, thus augmenting bone-to-tendon healing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adhesives
  • Animals
  • Anterior Cruciate Ligament Reconstruction
  • Biocompatible Materials / chemistry*
  • Bivalvia / chemistry*
  • Bone Marrow Cells
  • Bone and Bones
  • Calcium Phosphates / chemistry*
  • Citrates / chemistry*
  • Mesenchymal Stem Cells
  • Molecular Structure
  • Osteogenesis
  • Rats
  • Stress, Mechanical
  • Tendons

Substances

  • Adhesives
  • Biocompatible Materials
  • Calcium Phosphates
  • Citrates
  • whitlockite