A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity

Science. 2021 Oct;374(6563):eabf2911. doi: 10.1126/science.abf2911. Epub 2021 Oct 1.

Abstract

[Figure: see text].

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Carcinoma, Squamous Cell / genetics
  • Carcinoma, Squamous Cell / metabolism*
  • Cell Line, Tumor
  • Cell Movement
  • Class I Phosphatidylinositol 3-Kinases / genetics*
  • Class I Phosphatidylinositol 3-Kinases / metabolism*
  • Drug Resistance, Neoplasm / genetics*
  • Female
  • Head and Neck Neoplasms / genetics
  • Head and Neck Neoplasms / metabolism*
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Mice
  • Mice, Nude
  • Microfilament Proteins / metabolism
  • Mutation
  • Protein Interaction Maps*
  • Receptor, Fibroblast Growth Factor, Type 3 / metabolism
  • Xenograft Model Antitumor Assays

Substances

  • CCDC88C protein, human
  • Intracellular Signaling Peptides and Proteins
  • Microfilament Proteins
  • Class I Phosphatidylinositol 3-Kinases
  • PIK3CA protein, human
  • FGFR3 protein, human
  • Receptor, Fibroblast Growth Factor, Type 3