The retrosplenial cortex as a possible "sensory integration" area: A neural network modeling approach of the differential outcomes effect in negative patterning

Neurobiol Learn Mem. 2021 Nov:185:107527. doi: 10.1016/j.nlm.2021.107527. Epub 2021 Sep 27.

Abstract

We explored the hypothesis that learning a Pavlovian negative patterning task would be facilitated when training with differential, as opposed to non-differential, reinforcing outcomes. Two groups of rats received pairings of one visual and one auditory stimulus with food reward when these stimuli were presented on separate training trials, but without reward when both stimuli were presented on simultaneous stimulus compound trials (V+, A+, AV-; similar to an XOR problem). For Group Differential, each stimulus was separately paired with distinctively tasting food rewards, whereas for Group Non-Differential each stimulus was randomly paired with both food reward types across different stimulus element trials. We observed that rats learned the negative patterning task more rapidly and effectively when trained with differential outcomes. These data support a multi-layered connectionist model introduced by Delamater (2012) in which a multi-modal processing structure plays the role of a "sensory integration" area like that hypothesized for the retrosplenial cortex by Dave Bucci and his colleagues (e.g., Todd, Fournier, & Bucci, 2019). We discuss how such a region may develop different "negative occasion setting" and "configural inhibition" mechanisms in solving negative patterning and related tasks.

Keywords: Connectionist modeling; Differential outcome effect; Negative patterning; Pavlovian learning; Retrosplenial cortex.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acoustic Stimulation
  • Animals
  • Conditioning, Operant / physiology
  • Gyrus Cinguli / physiology*
  • Male
  • Nerve Net / physiology*
  • Photic Stimulation
  • Rats
  • Rats, Long-Evans
  • Reward