Well-Defined NHC-Ni Complexes as Catalysts: Preparation, Structures and Mechanistic Studies in Cross-Coupling Reactions

Abstract

Developmental studies are ongoing to discover a way to utilise new N-heterocyclic carbene (NHC)-Ni complexes as catalysts. Using a bulky NHC ligand, it is possible to synthesise an NHC/phosphine-mixed heteroleptic Ni(II) complex, which can serve as an excellent catalyst for various cross-coupling reactions. During the study of the reaction mechanisms using these Ni complexes, NHC-Ni(I) complexes were accidentally discovered, and it was observed that they exhibit excellent catalytic activity for cross-coupling reactions. The possibility of the presence of NHC-Ni(I) intermediates in these catalytic reaction pathways has been experimentally demonstrated. Depending on the type of reaction, dinuclear Ni(I) and mononuclear Ni(I) complexes can function as intermediates. The results of the investigation of each reaction mechanism are summarised, and the prospects are described.

Keywords: Carbene; Cross-coupling; Homogeneous catalysis; NHC ligand; Nickel.