Noncoding RNAs in triple negative breast cancer: Mechanisms for chemoresistance

Cancer Lett. 2021 Dec 28:523:100-110. doi: 10.1016/j.canlet.2021.09.038. Epub 2021 Sep 30.

Abstract

Triple-negative breast cancer (TNBC) is the most aggressive subtype among breast cancers with high recurrence and this condition is partly due to chemoresistance. Therefore, fully understanding the mechanism of TNBC-resistance is the key to overcoming chemoresistance, which will be an effective strategy for TNBC therapy. Various potential mechanisms involved in the chemoresistance of TNBC have been investigated and indicated that noncoding RNAs (ncRNAs) especially microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) take part in most TNBC resistance. The ncRNA-induced chemoresistance process is involved in the alteration of many activities. here, we mainly summarize the mechanisms of ncRNAs in the chemoresistance of TNBC and discuss the potential clinical application of ncRNAs in the treatment of TNBC, indicating that targeting ncRNAs might be a promising strategy for resensitization to chemotherapies.

Keywords: Breast cancer; Drug resistance; Long noncoding RNAs; Mechanisms; TNBC treatment; microRNAs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis
  • Autophagy / physiology
  • DNA Repair
  • Drug Delivery Systems
  • Drug Resistance, Neoplasm
  • Epithelial-Mesenchymal Transition
  • Humans
  • MicroRNAs / physiology
  • RNA, Long Noncoding / antagonists & inhibitors
  • RNA, Long Noncoding / physiology*
  • Triple Negative Breast Neoplasms / drug therapy*
  • Triple Negative Breast Neoplasms / genetics
  • Tumor Microenvironment

Substances

  • MicroRNAs
  • RNA, Long Noncoding