Effect of nicotine chewing gum on salivary secretion

Swed Dent J. 1986;10(3):93-6.


The effect of nicotine, placebo for nicotine or menthol-tasting chewing gums on salivation was studied in 25 healthy volunteers. The chewing of a commercial nicotine containing (2 mg) chewing gum (Nicorette) did not give a larger rate of salivation than did the chewing of a placebo chewing gum. For both types of chewing gums the rate of salivation was highest during the initial 5 min and it decreased thereafter. Menthol-tasting chewing gum gave a significantly higher amount of stimulated saliva. It is concluded that the addition of nicotine to a chewing gum does not provide an additional stimulus for salivation.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Chewing Gum*
  • Female
  • Humans
  • Male
  • Menthol / pharmacology
  • Nicotine / pharmacology*
  • Placebos
  • Saliva / drug effects
  • Saliva / metabolism*
  • Salivation / drug effects
  • Time Factors


  • Chewing Gum
  • Placebos
  • Menthol
  • Nicotine