The Association of Age at Diagnosis of Hypertension With Brain Structure and Incident Dementia in the UK Biobank

doi:10.1161/HYPERTENSIONAHA.121.17608

. 2021 Nov;78(5):1463-1474.

doi: 10.1161/HYPERTENSIONAHA.121.17608. Epub 2021 Oct 4.

The Association of Age at Diagnosis of Hypertension With Brain Structure and Incident Dementia in the UK Biobank

Xianwen Shang^{1

2}, Edward Hill^{3

4}, Zhuoting Zhu^{1

2}, Jiahao Liu⁵, B Zongyuan Ge⁶, Wei Wang⁷, Mingguang He^{1

7

8}

Affiliations

¹ Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China (X.S., Z.Z., M.H.).
² Guangdong Cardiovsacular Institute, Guangzhou, China (X.S., Z.Z.).
³ Department of Medicine (Royal Melbourne Hospital) (E.H.), University of Melbourne, VIC, Australia.
⁴ Wicking Dementia Research and Education Centre, University of Tasmania, Australia (E.H.).
⁵ Melbourne School of Population and Global Health (J.L.), University of Melbourne, VIC, Australia.
⁶ Monash e-Research Center, Faculty of Engineering, Airdoc Research, Nvidia AI Technology Research Center, Monash University, Melbourne, VIC, Australia (Z.G.).
⁷ State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China (W.W., M.H.).
⁸ Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, VIC, Australia (M.H.).

PMID: 34601962
DOI: 10.1161/HYPERTENSIONAHA.121.17608

Free article

The Association of Age at Diagnosis of Hypertension With Brain Structure and Incident Dementia in the UK Biobank

Xianwen Shang et al. Hypertension. 2021 Nov.

Free article

. 2021 Nov;78(5):1463-1474.

doi: 10.1161/HYPERTENSIONAHA.121.17608. Epub 2021 Oct 4.

Authors

Xianwen Shang^{1

2}, Edward Hill^{3

4}, Zhuoting Zhu^{1

2}, Jiahao Liu⁵, B Zongyuan Ge⁶, Wei Wang⁷, Mingguang He^{1

7

8}

Affiliations

¹ Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China (X.S., Z.Z., M.H.).
² Guangdong Cardiovsacular Institute, Guangzhou, China (X.S., Z.Z.).
³ Department of Medicine (Royal Melbourne Hospital) (E.H.), University of Melbourne, VIC, Australia.
⁴ Wicking Dementia Research and Education Centre, University of Tasmania, Australia (E.H.).
⁵ Melbourne School of Population and Global Health (J.L.), University of Melbourne, VIC, Australia.
⁶ Monash e-Research Center, Faculty of Engineering, Airdoc Research, Nvidia AI Technology Research Center, Monash University, Melbourne, VIC, Australia (Z.G.).
⁷ State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China (W.W., M.H.).
⁸ Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, VIC, Australia (M.H.).

PMID: 34601962
DOI: 10.1161/HYPERTENSIONAHA.121.17608

Abstract

[Figure: see text].

Keywords: adult; dementia; hypertension; magnetic resonance imaging; propensity score.

PubMed Disclaimer

Comment in

Age of Hypertension Onset: Potential for Improving Risk Estimation and Hypertension Management?
Suvila K, Niiranen TJ. Suvila K, et al. Hypertension. 2021 Nov;78(5):1475-1477. doi: 10.1161/HYPERTENSIONAHA.121.18197. Epub 2021 Oct 13. Hypertension. 2021. PMID: 34644170 No abstract available.

Cited by

Age of hypertension onset and cognitive function in the elderly: an observational study from the NHANES 2011-2014.
Wu M, Lu C, Chen F, Fan Y, Li G, Zhou L. Wu M, et al. Eur Geriatr Med. 2024 Jan 17. doi: 10.1007/s41999-023-00920-9. Online ahead of print. Eur Geriatr Med. 2024. PMID: 38231294
Midlife hypertension is a risk factor for some, but not all, domains of cognitive decline in later life: a systematic review and meta-analysis.
Joyce OC, McHugh C, Mockler D, Wilson F, Kelly ÁM. Joyce OC, et al. J Hypertens. 2024 Feb 1;42(2):205-223. doi: 10.1097/HJH.0000000000003614. Epub 2023 Nov 14. J Hypertens. 2024. PMID: 37937515 Free PMC article.
Age-associated increases in middle cerebral artery pulsatility differ between men and women.
Lefferts WK, Reed KS, Rosonke RE, Augustine JA, Moreau KL. Lefferts WK, et al. Am J Physiol Heart Circ Physiol. 2023 Nov 1;325(5):H1118-H1125. doi: 10.1152/ajpheart.00453.2023. Epub 2023 Sep 8. Am J Physiol Heart Circ Physiol. 2023. PMID: 37682233 Free PMC article.
Association of physical activity with dementia and cognitive decline in UK Biobank.
Huang X, Tan CS, Kandiah N, Hilal S. Huang X, et al. Alzheimers Dement (Amst). 2023 Sep 4;15(3):e12476. doi: 10.1002/dad2.12476. eCollection 2023 Jul-Sep. Alzheimers Dement (Amst). 2023. PMID: 37671035 Free PMC article.
Incidence of Alzheimer's Disease in Men with Late-Life Hypertension Is Ameliorated by FOXO3 Longevity Genotype.
Chen R, Morris BJ, Donlon TA, Ross GW, Kallianpur KJ, Allsopp RC, Nakagawa K, Willcox BJ, Masaki KH. Chen R, et al. J Alzheimers Dis. 2023;95(1):79-91. doi: 10.3233/JAD-230350. J Alzheimers Dis. 2023. PMID: 37483002 Free PMC article.

See all "Cited by" articles

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

The Association of Age at Diagnosis of Hypertension With Brain Structure and Incident Dementia in the UK Biobank

Affiliations

The Association of Age at Diagnosis of Hypertension With Brain Structure and Incident Dementia in the UK Biobank

Authors

Affiliations

Abstract

Comment in

Similar articles

Cited by

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Abstract

Comment in

Similar articles

Cited by

Publication types

MeSH terms

Related information

Grants and funding

LinkOut - more resources

Full Text Sources

Medical