Medication Management of Selected Pathological Jaw Lesions

Oral Maxillofac Surg Clin North Am. 2022 Feb;34(1):179-187. doi: 10.1016/j.coms.2021.08.004. Epub 2021 Oct 1.


Most jaw lesions are treated surgically. Areas of abnormal proliferation or destruction in bone are commonly treated by regional curettage, excision, or resection. However, surgery is invasive and leaves a defect where the lesion was removed. Surgical trauma to adjacent healthy tissue, including vital neurovascular bundles is often unavoidable, and can be especially traumatizing to the pediatric patient. Select jaw lesions with well-studied nonsurgical pharmaceutical treatments are presented here.

Keywords: ABC; CGCG; Fibrous dysplasia; Jaw lesions; MRONJ; Nonsurgical; Oral surgery; Paget’s disease of bone.

Publication types

  • Review

MeSH terms

  • Bisphosphonate-Associated Osteonecrosis of the Jaw*
  • Bone Density Conservation Agents*
  • Child
  • Diphosphonates
  • Humans
  • Medication Therapy Management


  • Bone Density Conservation Agents
  • Diphosphonates