Inhibitory Fcγ Receptor and Paired Immunoglobulin Type 2 Receptor Alpha Genotypes in Alzheimer's Disease

J Alzheimers Dis. 2021;84(3):965-968. doi: 10.3233/JAD-215174.


We investigated whether FCGRIIB (rs1050501 C/T) and PILRA (rs1859788 A/G) genotypes contributed to the development of Alzheimer's disease (AD). We genotyped 209 African American (AA) and 638 European American (EA) participants for the FCGRIIB and PILRA alleles. In the AA cohort, subjects homozygous for the C allele of FCGRIIB were more than 4 times as likely to develop AD as those homozygous for the alternative T allele. This SNP also interacted with PILRA: participants who were the carriers of the FCGRIIB C allele and PILRA A allele were 3 times as likely to develop AD as those who lacked these alleles.

Keywords: Amyloid-β; FCGRIIB; PILRA; neurotoxicity.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Alleles
  • Alzheimer Disease / genetics*
  • Black or African American / genetics
  • Black or African American / statistics & numerical data
  • Genotype*
  • Humans
  • Membrane Glycoproteins / genetics*
  • Prospective Studies
  • Receptors, IgG / genetics*
  • Receptors, Immunologic / genetics*
  • United States
  • White People / genetics
  • White People / statistics & numerical data


  • Membrane Glycoproteins
  • PILRA protein, human
  • Receptors, IgG
  • Receptors, Immunologic