BOP1 Used as a Novel Prognostic Marker and Correlated with Tumor Microenvironment in Pan-Cancer

Wei Li; Peipei Song; Mengyuan Zhao; Lina Gao; Jianqin Xie; Chongge You

doi:10.1155/2021/3603030

BOP1 Used as a Novel Prognostic Marker and Correlated with Tumor Microenvironment in Pan-Cancer

J Oncol. 2021 Sep 22:2021:3603030. doi: 10.1155/2021/3603030. eCollection 2021.

Authors

Wei Li^{1

2}, Peipei Song¹, Mengyuan Zhao¹, Lina Gao¹, Jianqin Xie¹, Chongge You¹

Affiliations

¹ Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou 730030, China.
² Department of Geriatrics, Xiangya Hospital, Central South University, Changsha 410008, China.

Abstract

Previous studies have indicated the important role of block of proliferation 1 (BOP1) in the progression of several malignant tumors; no comprehensive pan-cancer analysis of BOP1 has been performed. Here, we aim to systematically identify the expression, prognostic value, and potential immunological functions of BOP1 in 33 malignancies. We obtained the gene expression data and clinical information from multiple public databases to assess the expression level and prognostic value of BOP1 in 33 cancers. We also analyzed the relationship between BOP1 expression and DNA methylation, tumor microenvironment (TME), microsatellite instability (MSI), tumor mutational burden (TMB), and immune checkpoints. Moreover, we conducted gene set enrichment analysis (GSEA) to investigate the biological function and signal transduction pathways of BOP1 in different types of tumors. Finally, we validated the expression of BOP1 in lung cancer cell line and detected the influence of BOP1 on lung cancer cell migration and the expression of epithelial-mesenchymal transition- (EMT-) related genes. Collectively, our findings elucidated that BOP1 has the potential to be a promising molecular prognostic biomarker for predicting poor survival in various malignant tumors, as well as a cancer-promoting gene involved in tumorigenesis and tumor immunity.