Calcific Aortic Stenosis-A Review on Acquired Mechanisms of the Disease and Treatments

Banafsheh Zebhi; Mohamad Lazkani; David Bark Jr

doi:10.3389/fcvm.2021.734175

Calcific Aortic Stenosis-A Review on Acquired Mechanisms of the Disease and Treatments

Front Cardiovasc Med. 2021 Sep 17:8:734175. doi: 10.3389/fcvm.2021.734175. eCollection 2021.

Authors

Banafsheh Zebhi¹, Mohamad Lazkani², David Bark Jr^{3

4}

Affiliations

¹ Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, United States.
² Medical Center of the Rockies, University of Colorado Health, Loveland, CO, United States.
³ Department of Pediatrics, Washington University in Saint Louis, Saint Louis, MO, United States.
⁴ Department of Biomedical Engineering, Washington University in Saint Louis, Saint Louis, MO, United States.

Abstract

Calcific aortic stenosis is a progressive disease that has become more prevalent in recent decades. Despite advances in research to uncover underlying biomechanisms, and development of new generations of prosthetic valves and replacement techniques, management of calcific aortic stenosis still comes with unresolved complications. In this review, we highlight underlying molecular mechanisms of acquired aortic stenosis calcification in relation to hemodynamics, complications related to the disease, diagnostic methods, and evolving treatment practices for calcific aortic stenosis.

Keywords: basilica; calcific aortic stenosis; coronary obstruction; hemodynamics; prosthetic heart valve; transcatheter heart valve.

Publication types

Review