Masqueraders: how to identify atypical diabetes in primary care

J Osteopath Med. 2021 Oct 5;121(12):899-904. doi: 10.1515/jom-2021-0129.

Abstract

Diabetes mellitus is a complex set of conditions that impacts 34 million Americans. While type 1 diabetes, type 2 diabetes, and gestational diabetes are most frequently encountered, there are many other types of diabetes with which healthcare providers are less familiar. These atypical forms of diabetes make up nearly 10% of diabetes cases and can masquerade as type 1 or 2 diabetes mellitus (T1DM or T2DM), and the treatment may not be optimized if the diagnosis is not accurate. Atypical forms include monogenic diabetes (formally known as maturity-onset diabetes of the young [MODY]), latent autoimmune diabetes of the adult (LADA), ketosis-prone diabetes, and secondary diabetes. This paper will detail the defining characteristics of each atypical form and demonstrate how they can masquerade as type 1 or 2 diabetes mellitus. Gestational diabetes mellitus will not be discussed in this article.

Keywords: atypical diabetes; latent autoimmune diabetes of the adult; monogenic diabetes; secondary diabetes.

MeSH terms

  • Diabetes Mellitus, Type 1* / diagnosis
  • Diabetes Mellitus, Type 2* / diagnosis
  • Humans
  • Primary Health Care