Outcomes associated with different vaccines in individuals with bipolar disorder and impact on the current COVID-19 pandemic- a systematic review

Eur Neuropsychopharmacol. 2022 Jan:54:90-99. doi: 10.1016/j.euroneuro.2021.09.001. Epub 2021 Sep 10.


Bipolar disorder (BD) might be associated with higher infection rates of coronavirus disease (COVID-19) which in turn could result in worsening the clinical course and outcome. This may be due to a high prevalence of somatic comorbidities and an increased risk of delays in and poorer treatment of somatic disease in patients with severe mental illness in general. Vaccination is the most important public health intervention to tackle the ongoing pandemic. We undertook a systematic review regarding the data on vaccinations in individuals with BD. Proportion of prevalence rates, efficacy and specific side effects of vaccinations and in individuals with BD were searched. Results show that only five studies have investigated vaccinations in individuals with BD, which substantially limits the interpretation of overall findings. Studies on antibody production after vaccinations in BD are very limited and results are inconsistent. Also, the evidence-based science on side effects of vaccinations in individuals with BD so far is poor.

Keywords: Bipolar disorder; COVID-19; Infectious diseases; Systematic review; Vaccination.

Publication types

  • Systematic Review

MeSH terms

  • Bipolar Disorder* / epidemiology
  • COVID-19*
  • Communicable Disease Control
  • Communicable Diseases
  • Humans
  • Pandemics
  • SARS-CoV-2
  • Vaccines* / administration & dosage
  • Vaccines* / adverse effects


  • Vaccines