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Randomized Controlled Trial
. 2021 Dec 1;156(12):1179-1181.
doi: 10.1001/jamasurg.2021.5003.

Factors Associated With Primary Nonresponsiveness to Antibiotics in Adults With Uncomplicated Acute Appendicitis: A Prespecified Secondary Analysis of a Randomized Clinical Trial

Jussi Haijanen  1 , Suvi Sippola  1 , Eliisa Löyttyniemi  2 , Saija Hurme  2 , Juha Grönroos  1 , Tero Rautio  3 , Paulina Salminen  1
Affiliations
Randomized Controlled Trial

Factors Associated With Primary Nonresponsiveness to Antibiotics in Adults With Uncomplicated Acute Appendicitis: A Prespecified Secondary Analysis of a Randomized Clinical Trial

Jussi Haijanen et al. JAMA Surg. .

Abstract

This secondary analysis of a randomized clinical trial assesses potential preintervention findings associated with primary nonresponsiveness to antibiotics in adults with uncomplicates acute appendicitis.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Haijanen reported grants from Orion Research Foundation, grants from Government research grant awarded to Turku University Hospital, grants from Gastroenterological Research Foundation, grants from Paulo Foundation, and grants from Finnish medical Foundation during the conduct of the study. Dr Sippola reported grants from the Orion Research Foundation, grants from the Gastroenterological Research Foundation, and grants from a Government research grant awarded to Turku University Hospital during the conduct of the study; grants from the Mary and Georg C. Ehrnrooth Foundation and grants from the Finnish Medical Foundation outside the submitted work. Dr Salminen reported grants from Sigrid Juselius Foundation Research grant and grants from Academy of Finland Research grant during the conduct of the study; personal fees from Orion Pharma lecture fee and personal fees from Merck lecture fee outside the submitted work. No other disclosures were reported.

Figures

Figure.
Figure.. Significant Preintervention Factors on Admission Associated With Primary Nonresponsiveness to Antibiotic Therapy
Adjusted relative risk (RR) with 95% CIs. The model was analyzed with log-binomial model. For 5 patients, data for body temperature on admission was unavailable. aPatients with primary nonresponsiveness to antibiotics (ie, undergoing appendectomy during primary hospitalization with a finding of complicated acute appendicitis at surgery and histologic findings). Two patients with nonresponsiveness had both appendiceal diameter greater than or equal to 15 mm and body temperature greater than 38 °C at admission.
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References

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